Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

Learn about the flu shot, COVID-19 vaccine, and our masking policy »

Stanford Health Care

PULMONARY-DISEASE AS A COMPLICATION OF CHLOROZOTOCIN CHEMOTHERAPY CANCER TREATMENT REPORTS Ahlgren, J. D., Smith, F. P., KERWIN, D. M., Sikic, B. I., Weiner, J. H., SCHEIN, P. S. 1981; 65 (3-4): 223-229

Abstract

Two of 200 patients treated with chlorozotocin have evidenced interstitial pulmonary disease. The cumulative doses of chlorozotocin were 480 and 670 mg/m2 when symptoms developed. Pulmonary function tests in both patients showed impaired diffusion, and an alveolar-arterial gradient which worsened with exercise. Open-lung biopsy in one patient showed typical interstitial inflammation and early fibrosis, and excluded lymphangitic spread of tumor. Discontinuation of chlorozotocin resulted in either improvement or stabilization of the pulmonary disease.

View details for Web of Science ID A1981LV60300007

View details for PubMedID 6453644