Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

Learn about the flu shot, COVID-19 vaccine, and our masking policy »

Stanford Health Care

CHOLINERGIC ENHANCEMENT OF PENICILLIN-INDUCED EPILEPTIFORM DISCHARGES IN PYRAMIDAL NEURONS OF THE GUINEA-PIG HIPPOCAMPUS BRAIN RESEARCH Kriegstein, A. R., Suppes, T., Prince, D. A. 1983; 266 (1): 137-142

Abstract

Acetylcholine (1-20 mM) was applied to guinea pig hippocampal slices bathed in normal and penicillin-containing media. Recordings in the CA 1 pyramidal cell layer in the presence of penicillin showed that acetylcholine caused a prolonged enhancement of the extracellular field potential. Intracellular recordings documented an increase in duration of cell bursting, a decrease in burst afterhyperpolarization, and a membrane depolarization lasting 1-5 min. These results suggest that the actions of acetylcholine to increase membrane excitability interact with penicillin-induced disinhibition to enhance hippocampal epileptogenesis.

View details for Web of Science ID A1983QM90500013

View details for PubMedID 6850341