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HEPATIC CYTOCHROME P-450-DEPENDENT METABOLISM AND ENZYMATIC CONJUGATION OF FOREIGN COMPOUNDS IN VITAMIN-A-DEFICIENT RATS PHARMACOLOGY SIDDIK, Z. H., Drew, R., LITTERST, C. L., Mimnaugh, E. G., Sikic, B. I., Gram, T. E. 1980; 21 (6): 383-390

Abstract

The temporal effects of vitamin A deficiency on hepatic cytochrome P-450-dependent and conjugation reactions were studied in the rat. Cytochrome P-450 levels and N-methyl-p-chloroaniline N-demethylase activity were significantly reduced in the deficient animals. No other changes in parameters dependent on cytochrome P-450 were observed in vitro. Decreases in hepatic cytochrome P-450 were accompanied by a prolongation in hexobarbital sleeping times in deficient animals. The p-aminobenzoic acid N-acetyltransferase activity was higher in the deficient animals at 8 weeks, but by 10 weeks the activity in fact was significantly lower as compared to controls. Activities of 'native' and UDP N-acetylglucosamine 'activated' UDP-glucuronyltransferase were reduced in vitamin A deficiency. In contrast to this general pattern of impaired drug metabolism in vitamin A deficiency, glutathione S-aryltransferase activity was markedly enhanced at all time points from 4 to 10 weeks. Activities of this enzyme were twice controls at 6 weeks, a time at which no other enzyme changes were observed.

View details for Web of Science ID A1980KX52600003

View details for PubMedID 7220590