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HUMAN CD5+ B-LYMPHOCYTES (B-1 CELLS) DECREASE IN PERIPHERAL-BLOOD DURING PREGNANCY JOURNAL OF REPRODUCTIVE IMMUNOLOGY Bhat, N. M., Mithal, A., Bieber, M. M., Herzenberg, L. A., Teng, N. N. 1995; 28 (1): 53-60

Abstract

Pregnancy is a unique immunologic state where a natural homeostasis exists between antigenically different tissues. Several earlier studies have addressed the fluctuations in the number and/or function of lymphocytes, including B cells during pregnancy, but changes within the subsets of B lymphocytes, conventional (CD5-) and B-1 (CD5+), have not been addressed. Here we demonstrate that the frequency of B-1 cells decreases dramatically during pregnancy, whereas the frequency of conventional B cells remains relatively constant. The missing B-1 cells return to pre-pregnancy levels 8-10 weeks after parturition. The polyreactive autoantibodies secreted by B-1 cells have been implicated in autoimmunity and immune regulation. The possible role of B-1 cells during pregnancy will be discussed in that context.

View details for Web of Science ID A1995QH79400005

View details for PubMedID 7537825