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The integrin alpha(V)beta(6) binds and activates latent TGF beta 3 FEBS LETTERS Annes, J. P., RIFKIN, D. B., Munger, J. S. 2002; 511 (1-3): 65-68

Abstract

Transforming growth factors-beta (TGFbeta1, 2 and 3) are secreted in a complex with their propeptides (latency-associated peptide 1 (LAP1), 2 and 3). TGFbeta signaling requires the dissociation of LAP and TGFbeta, a process termed latent TGFbeta activation. This process is a critical but incompletely understood step in the regulation of TGFbeta function. In particular, the extent to which activation mechanisms differ among the three TGFbeta isoforms is relatively unexplored. We show here that alphaVbeta6 binds and activates latent TGFbeta3.

View details for Web of Science ID 000173628000013

View details for PubMedID 11821050