Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

Learn about the flu shot, COVID-19 vaccine, and our masking policy »

Stanford Health Care

DEFICIENCY IN ANTIBODY-RESPONSE TO HUMAN CYTOMEGALOVIRUS GLYCOPROTEIN GH IN HUMAN IMMUNODEFICIENCY VIRUS-TREATED PATIENTS AT RISK FOR CYTOMEGALOVIRUS RETINITIS JOURNAL OF INFECTIOUS DISEASES Rasmussen, L., Morris, S., Wolitz, R., Dowling, A., Fessell, J., Holodniy, M., Merigan, T. C. 1994; 170 (3): 673-677

Abstract

Human immunodeficiency virus (HIV)-infected patients at risk for symptomatic human cytomegalovirus (CMV) infection were studied for serum antibody to CMV glycoproteins gH and gB. Antibody titers to gB in HIV-seropositive patients, irrespective of CD4 cell counts or presence of CMV retinitis, were significantly higher than titers in HIV-seronegative, CMV-seropositive patients but were comparable to titers detected in HIV-seronegative patients with CMV mononucleosis. In contrast, antibody to gH was rarely detected in HIV-seropositive patients with CD4 cell counts > 100/mm3 compared with patients with counts > 100/mm3. The inability to detect gH antibody at a time of high risk for symptomatic CMV retinitis suggests that immune intervention with either gH-specific vaccine or passive immunotherapy may benefit HIV-infected persons at risk for symptomatic CMV disease.

View details for Web of Science ID A1994PE26500026

View details for PubMedID 7915750