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HOMOLOGIES BETWEEN T-CELL RECEPTOR JUNCTIONAL SEQUENCES UNIQUE TO MULTIPLE-SCLEROSIS AND T-CELLS MEDIATING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS JOURNAL OF CLINICAL INVESTIGATION Allegretta, M., Albertini, R. J., Howell, M. D., Smith, L. R., Martin, R., McFarland, H. F., Sriram, S., Brostoff, S., Steinman, L. 1994; 94 (1): 105-109

Abstract

The selection of T cell clones with mutations in the hypoxanthine guanine phosphoribosyltransferase (hprt) gene has been used to isolate T cells reactive to myelin basic protein (MBP) in patients with multiple sclerosis (MS). These T cell clones are activated in vivo, and are not found in healthy individuals. The third complementarity determining regions (CDR3) of the T cell receptor (TCR) alpha and beta chains are the putative contact sites for peptide fragments of MBP bound in the groove of the HLA molecule. The TCR V gene usage and CDR3s of these MBP-reactive hprt-T cell clones are homologous to TCRs from other T cells relevant to MS, including T cells causing experimental allergic encephalomyelitis (EAE) and T cells found in brain lesions and in the cerebrospinal fluid (CSF) of MS patients. In vivo activated MBP-reactive T cells in MS patients may be critical in the pathogenesis of MS.

View details for Web of Science ID A1994NW49600016

View details for PubMedID 8040252