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REPEATED TREATMENT WITH CHIMERIC ANTI-CD4 ANTIBODY IN MULTIPLE-SCLEROSIS ANNALS OF NEUROLOGY Lindsey, J. W., Hodgkinson, S., Mehta, R., Mitchell, D., ENZMANN, D., Steinman, L. 1994; 36 (2): 183-189

Abstract

We treated 21 multiple sclerosis patients with two to four doses of cM-T412, a chimeric monoclonal antibody against the CD4 antigen found on helper/inducer T lymphocytes. The mean number (+/- standard error) of circulating CD4 lymphocytes decreased from 888 (+/- 81) cells/mm3 at baseline to 246 (+/- 18) after treatment. At 1 year after the last treatment, the CD4 count had recovered to only 335 (+/- 32). The antibody had no effect on CD8 lymphocytes, B lymphocytes, or other leukocytes. Side effects were minimal. Despite the prolonged depletion of CD4 lymphocytes, no opportunistic infections occurred. Only 1 patient had a possible allergic reaction. Most patients were clinically stable, but a few progressed. We conclude that repeated treatment with cM-T412 is effective in reducing the number of circulating CD4 lymphocytes and has no limiting side effects.

View details for Web of Science ID A1994PB26000009

View details for PubMedID 8053654