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Role of nonspecific cross-reacting antigen, a CD66 cluster antigen, in activation of human granulocytes

Role of nonspecific cross-reacting antigen, a CD66 cluster antigen, in activation of human granulocytes INFECTION AND IMMUNITY Klein, M. L., McGhee, S. A., Baranian, J., Stevens, L., Hefta, S. A. 1996; 64 (11): 4574-4579

Abstract

Nonspecific cross-reacting antigen (NCA) is the name of a family of highly glycosylated bacterial-binding receptors found on human granulocytes and other tissues. These glycoproteins are members of the immunoglobulin supergene family and are related structurally to carcinoembryonic antigen. In this study, we demonstrate that ligation of granulocyte NCA results in the activation of the cells, as measured by degranulation and the flux of intracellular calcium. These studies further the proposition that NCA has a function in the immune response of granulocytes against bacterial infections.

View details for Web of Science ID A1996VP42800024

View details for PubMedID 8890209