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Recombination between sequences of hepatitis B virus from different genotypes

Recombination between sequences of hepatitis B virus from different genotypes JOURNAL OF MOLECULAR EVOLUTION Bollyky, P. L., Rambaut, A., Harvey, P. H., HOLMES, E. C. 1996; 42 (2): 97-102

Abstract

A comparison of 25 hepatitis B virus (HBV) isolates for which complete genome sequences are available revealed two that occupied different positions in phylogenetic trees reconstructed from different open reading frames. Further analysis indicated that this incongruence was the result of recombination between viruses of different genomic and antigenic types. Both putative recombinants originated from geographic regions where multiple genotypes are known to cocirculate. A search of the sequence databases showed evidence of similar intergenotypic recombinants. These observations indicate that recombination between divergent strains may represent an important source of genetic variation in HBV.

View details for Web of Science ID A1996UC69800005

View details for PubMedID 8919861