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Stanford Health Care

Pathophysiology of reduced glomerular filtration rate in delayed graft function CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION Scandling, J. D., Myers, B. D. 1997; 6 (4): 405-409

Abstract

Delayed graft function is a form of postischemic acute renal failure. It lowers glomerular filtration rate in large part by depressing the glomerular transcapillary hydraulic pressure difference, the driving force for the formation of filtrate. Loss of proximal tubule cell polarity, impaired sodium reabsorption and tubuloglomerular feedback-mediated afferent arteriolar constriction are all implicated. A link between delayed graft function and chronic allograft injury is evident. The ensuing impairment of graft survival makes urgent the need for further elucidation of delayed graft function and a search for an effective therapy.

View details for Web of Science ID A1997XK26600017

View details for PubMedID 9263693