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Progressive multifocal leukoencephalopathy in AIDS: initial and follow-up CT and MRI

Progressive multifocal leukoencephalopathy in AIDS: initial and follow-up CT and MRI NEURORADIOLOGY Thurnher, M. M., Thurnher, S. A., Muhlbauer, B., Hainfellner, J. A., Steuer, A., Fleischmann, D., Trattnig, S., Budka, H., Schindler, E. 1997; 39 (9): 611-618

Abstract

We sought to determine the value of follow-up CT and MRI in patients with acquired immuno-deficiency syndrome (AIDS) and progressive multifocal leukoencephalopathy (PML). We reviewed 50 CT and 19 MRI examinations performed in 21 biopsy- or autopsy-proven cases of PML; 17 patients had follow-up examinations (mean time 5.9 weeks). The radiological examinations were correlated with pathological findings at autopsy. On initial imaging studies, 73 lesions were found. On follow-up, the most striking feature was rapid progression in both size and number of the lesions (from a mean of 3.2 to 6.9 per patient). One third of the patients showed increasing mass effect. A central area suggesting necrosis, of variable size, was found in 12/16 patients. Autopsy revealed macroscopic necrotic changes in the lesions in 11/16 patients.

View details for Web of Science ID A1997XX51400001

View details for PubMedID 9335057