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Rapid synthesis of a 5 '-fluorinated oligodeoxy-nucleotide: A model antisense probe for use in imaging with positron emission tomography (PET) BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Pan, D. F., Gambhir, S. S., Toyokuni, T., Iyer, M. R., Acharya, N., Phelps, M. E., Barrio, J. R. 1998; 8 (11): 1317-1320

Abstract

5'-Deoxy-5'-fluoro-O4-methylthymidine was synthesized by the reaction of the corresponding 5'-O-tosylate with KF in the presence of Kryptofix [222] and coupled to a 5'-phosphoramidite-activated CPG-bound oligodeoxynucleotide. The sequence of reactions and purifications were accomplished within 4 h, a necessary condition of the development of radiofluorinated antisense oligodeoxynucleotide probe for use with PET.

View details for Web of Science ID 000074157600010

View details for PubMedID 9871758