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Whole-body, real-time preclinical imaging of quantum dot fluorescence with time-gated detection JOURNAL OF BIOMEDICAL OPTICS May, A., Bhaumik, S., Gambhir, S. S., Zhan, C., Yazdanfar, S. 2009; 14 (6)

Abstract

We describe a wide-field preclinical imaging system optimized for time-gated detection of quantum dot fluorescence emission. As compared to continuous wave measurements, image contrast was substantially improved by suppression of short-lifetime background autofluorescence. Real-time (8 frames/s) biological imaging of subcutaneous quantum dot injections is demonstrated simultaneously in multiple living mice.

View details for DOI 10.1117/1.3269675

View details for Web of Science ID 000274267900004

View details for PubMedID 20059235