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First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes 59th Annual Meeting of the American-Diabetes-Association Chase, H. P., Cuthbertson, D. D., Dolan, L. M., KAUFMAN, F., Krischer, J. P., Schatz, D. A., White, N. H., Wilson, D. M., Wolfsdorf, J. MOSBY-ELSEVIER. 2001: 244–49

Abstract

To determine the relationship between first-phase (1 minute + 3 minutes) insulin production during the intravenous glucose tolerance test (IV-GTT) and risk factors for developing type 1 diabetes.Relatives of persons with type 1 diabetes (n = 59,600) were screened for islet cell antibodies (ICAs). Subjects who had positive screening results underwent IV-GTT (> or =2 times), repeat ICA screening, insulin autoantibody (IAA) screening twice, and an oral glucose tolerance test.Of the 59,600 subjects in the study, 2199 (3.69%) had positive findings on initial ICA test. IV-GTTs were performed in 1622 subjects, with children <8 years having the lowest first-phase insulin release (FPIR) and subjects 8 to 20 years of age having the highest FPIR. The FPIR was lower for subjects with a confirmed positive ICA test result or a positive IAA test result, subjects with higher titers of ICA or IAA, and subjects who had an abnormal (impaired or diabetic) oral glucose tolerance test result.FPIR in the IV-GTT correlates strongly with risk factors for development of type 1 diabetes.

View details for DOI 10.1067/mpd.2001.111274

View details for Web of Science ID 000166905800018

View details for PubMedID 11174623