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High-Frequency Hippocampal Oscillations Activated by Optogenetic Stimulation of Transplanted Human ESC-Derived Neurons JOURNAL OF NEUROSCIENCE Pina-Crespo, J. C., Talantova, M., Cho, E., Soussou, W., Dolatabadi, N., Ryan, S. D., Ambasudhan, R., McKercher, S., Deisseroth, K., Lipton, S. A. 2012; 32 (45): 15837-15842

Abstract

After transplantation, individual stem cell-derived neurons can functionally integrate into the host CNS; however, evidence that neurons derived from transplanted human embryonic stem cells (hESCs) can drive endogenous neuronal network activity in CNS tissue is still lacking. Here, using multielectrode array recordings, we report activation of high-frequency oscillations in the ß and ? ranges (10-100 Hz) in the host hippocampal network via targeted optogenetic stimulation of transplanted hESC-derived neurons.

View details for DOI 10.1523/JNEUROSCI.3735-12.2012

View details for Web of Science ID 000310842000018

View details for PubMedID 23136422

View details for PubMedCentralID PMC3513396