Artificial zinc(II) complexes regulate cell cycle and apoptosis-related genes in tumor cell lines CHEMBIOCHEM Gao, J., Liu, Y., Zhou, Y., Boxer, L. M., Woolley, F. R., Zingaro, R. A. 2007; 8 (3): 332-340

Abstract

Various proteins involved in transcriptional regulation possess highly selective DNA-binding domains, known as zinc fingers. However, little is known about small-molecule zinc(II) complexes in the regulation of gene expression and programmed cell death. A new family of zinc(II) complexes is reported, which might be useful against human cancer cells. By using template synthesis and in vitro cell-line screening, a set of zinc(II) complexes has been found to induce apoptosis of cancer cells and display single-reagent in vitro cytotoxicity. The method used to synthesize the molecules resulted in "built-in" luminescent behavior. Confocal optical imaging clearly demonstrated penetration through the cell membrane by these metal complexes. We have discovered that C3, the meso-zinc(II) complex is an extremely efficient regulator of the cell cycle and anti-apoptosis genes bcl-2 and bcl-xL. This study provides a new insight into the development of zinc(II) complexes as potential drugs.

View details for DOI 10.1002/cbic.200600299

View details for Web of Science ID 000244440100010

View details for PubMedID 17203500