We report that a-tocotrienol quinone (ATQ3) is a metabolite of a-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging. ATQ3 is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial disease in open label studies. ATQ3 activity is dependent upon reversible 2e-redox-cycling. ATQ3 may represent a broader class of unappreciated dietary-derived phytomolecular redox motifs that digitally encode biochemical data using redox state as a means to sense and transfer information essential for cellular function.
View details for DOI 10.1016/j.bmcl.2011.04.085
View details for Web of Science ID 000291145900038
View details for PubMedID 21600768