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COMPARISON OF THE ELECTROCARDIOGRAPHIC EFFECT OF DOTHIEPIN AND AMITRIPTYLINE JOURNAL OF CLINICAL PSYCHIATRY Claghorn, J. L., Schroeder, J., Goldstein, B. J. 1984; 45 (7): 291-293

Abstract

Electrocardiograms of 65 patients treated with dothiepin, a sulphur substituted tricyclic antidepressant, were compared to those of 57 patients receiving amitriptyline and 62 patients given placebo. Amitriptyline produced an average heart rate increase of 10 beats/minute as compared to 5 beats/minute for dothiepin (p less than .02). Amitriptyline also produced a significant prolongation of the corrected QT interval as compared to both dothiepin and placebo (p less than .01 and p less than .001, respectively). Dothiepin had no significant effect on any index of myocardial conduction (PR interval, corrected QT interval, and QRS duration) as compared to placebo.

View details for Web of Science ID A1984TB30000002

View details for PubMedID 6376479