Transcriptional analysis of targets in multiple sclerosis NATURE REVIEWS IMMUNOLOGY Steinman, L., Zamvil, S. 2003; 3 (6): 483-492

Abstract

Large-scale analyses of messenger RNA transcripts and autoantibody responses, taken from the actual sites of disease, provide us with an unprecedented view of the complexity of autoimmunity. Despite an appreciation of the large number of pathways and pathological processes that are involved in these diseases, a few practical targets and several new strategies have emerged from these studies. This review focuses on multiple sclerosis and on the approaches that are being used to identify new targets that might be manipulated to control this disease.

View details for DOI 10.1038/nri1108

View details for Web of Science ID 000183423300014

View details for PubMedID 12776208