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Stanford Health Care

Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis NEURON Zamvil, S. S., Steinman, L. 2003; 38 (5): 685-688

Abstract

Multiple sclerosis (MS) is an autoimmune central nervous system (CNS) demyelinating disease that causes relapsing and chronic neurologic impairment. Recent observations have altered certain traditional concepts regarding MS pathogenesis. A greater diversity of cell types and molecules involved in MS is now evident. While remyelination can occur during the early inflammatory phase when damage may be reversible, it is impaired in the later stages, which involve axonal death. These observations have important therapeutic implications.

View details for Web of Science ID 000183361400005

View details for PubMedID 12797954