Motor performance and anatomic magnetic resonance imaging (MRI) of the basal ganglia in autism 57th Annual Meeting of the Society-of-Biological-Psychiatry Hardan, A. Y., Kilpatrick, M., Keshavan, M. S., Minshew, N. J. SAGE PUBLICATIONS INC. 2003: 317–24


This study was conducted to examine the volume of the basal ganglia in individuals with autism and to evaluate whether performance on specific motor tasks correlated with the volume of these structures. Volumetric measurements of the caudate nucleus and putamen were obtained from magnetic resonance images (MRI) of 40 non-mentally retarded individuals with autism and 41 healthy controls. Motor performance was assessed in these subjects by using the Finger Tapping Test, the Grooved Pegboard Test, and the measurement of Grip Strength. No volumetric differences of the basal ganglia were found between the two groups after adjusting for brain volume. The autistic subjects' performance was slower on the Grooved Pegboard Test and weaker on Grip Strength. Our findings suggest that the motor deficits observed in autism may not be related to structural abnormalities of the basal ganglia, and other brain regions, such as the cerebellum and the frontal lobe, may be involved in the pathophysiology of motor disturbances in autism.

View details for Web of Science ID 000183405600002

View details for PubMedID 12822815