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Delay correction for the assessment of blood-brain barrier permeability using first-pass dynamic perfusion CT. AJNR. American journal of neuroradiology Schneider, T., Hom, J., Bredno, J., Dankbaar, J. W., Cheng, S., Wintermark, M. 2011; 32 (7): E134-8

Abstract

Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.

View details for DOI 10.3174/ajnr.A2152

View details for PubMedID 20538824