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Sensitivity of multidrug-resistant tumor cell lines to immunologic effector cells CELLULAR IMMUNOLOGY SCHMIDTWOLF, I. G., Lefterova, P., Johnston, V., Scheffold, C., Csipai, M., Mehta, B. A., Tsuruo, T., Huhn, D., Negrin, R. S. 1996; 169 (1): 85-90

Abstract

The ability of malignant cells to survive exposure to cytotoxic agents is a major obstacle to cure in patients with cancer. Multidrug resistance and the expression of P-glycoprotein are emerging as a cause of chemotherapy failure. Immunologic effector cells such as lymphokine-activated killer (LAK) cells or cytokine-induced killer (CIK) cells are capable of killing a broad range of tumor cell lines or freshly isolated tumor cells. As demonstrated here, LAK, and CIK cells possess a high level of cytotoxic activity against tumor cell lines both resistant and sensitive to chemotherapeutic agents such as doxorubicin or vinblastine. CIK cells possessed a higher level of cytotoxic activity than LAK cells as determined by 51Cr release and a tumor colony assay. Monoclonal antibodies against P-glycoprotein did not block the lysis of tumor cells resistant to chemotherapy by CIK cells. In contrast, antibodies to LFA-1 and ICAM-1 blocked CIK cell-mediated tumor cell lysis. These data demonstrate that immunological approaches to cancer therapy may be useful in overcoming disease caused by drug resistance.

View details for Web of Science ID A1996UF06500012

View details for PubMedID 8612299