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NEUROOCULAR DAMAGE IN PEDIATRIC ONCOLOGY PATIENTS - PREDICTOR OF LONG-TERM VISUAL DISABILITY OR TOOL FOR LIMITING TOXICITY MEDICAL AND PEDIATRIC ONCOLOGY Newman, N. M., Donaldson, S., Dewit, S., King, O., Wilbur, J. R. 1986; 14 (5): 262-270

Abstract

We present a group of eight pediatric cancer patients with a spectrum of visual afferent pathway abnormalities. Changes include decreased visual acuity, visual field alterations, abnormal visual evoked potentials, changes in the optic disc and nerve fiber layer of the retina, radiation retinopathy, and CNS injury. These changes occur in long term survivors of pediatric malignancy (especially those with prolonged, multimodal, and multicourse therapy), but they may be minimally symptomatic. The changes appear to be analogous to the CNS changes (leukoencephalopathy) described in patients with leukemia and attributed to multimodal therapy. By taking advantage of opportunities to detect adverse effects earlier in the treatment course, the present excellent cure rate may be improved by refinements in therapy that also improve the quality of survival.

View details for Web of Science ID A1986F211000004

View details for PubMedID 3784980