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Sporadic Jakob-Creutzfeldt Disease Presenting as Primary Progressive Aphasia JAMA NEUROLOGY Johnson, D. Y., Dunkelberger, D. L., Henry, M., Haman, A., Greicius, M. D., Wong, K., DeArmond, S. J., Miller, B. L., Gorno-Tempini, M. L., Geschwind, M. D. 2013; 70 (2): 254-257

Abstract

To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia.Case report.Large referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease.Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease.Despite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease.These findings expand the differential of primary progressive aphasia to include prion disease.

View details for DOI 10.1001/2013.jamaneurol.139

View details for Web of Science ID 000316801300016

View details for PubMedID 23400721