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Experimental Models of Right Heart Failure: A Window for Translational Research in Pulmonary Hypertension SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE Guihaire, J., Bogaard, H. J., Flecher, E., Noly, P., Mercier, O., Haddad, F., Fadel, E. 2013; 34 (5): 689-699

Abstract

The right ventricle (RV) faces major changes in loading conditions associated with cardiovascular and pulmonary vascular disorders. Despite major pharmacological advances since the last decade, pulmonary arterial hypertension remains a deadly disease mainly secondary to the development of right ventricular failure (RVF). Several experimental models of RVF have been developed over the past three decades providing a particular insight in RV pathophysiology. Mechanisms involved in the transition from RV adaptive hypertrophy to maladaptive remodeling and failure in conditions of chronic RV pressure or volume overload are of a great interest but not yet completely understood. Further investigations are needed to find new therapeutic approaches for RVF. Current animal models and emerging concepts of translational RV research will be detailed in this review.

View details for DOI 10.1055/s-0033-1355444

View details for Web of Science ID 000324401900013

View details for PubMedID 24037635