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SEGREGATION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II INFECTIONS BY ANTIBODY REACTIVITY TO UNIQUE VIRAL EPITOPES JOURNAL OF INFECTIOUS DISEASES LIPKA, J. J., Miyoshi, I., Hadlock, K. G., Reyes, G. R., Chow, T. P., Blattner, W. A., Shaw, G. M., Hanson, C. V., Gallo, D., Chan, L., Foung, S. K. 1992; 165 (2): 268-272

Abstract

A recombinant protein of the human T cell lymphotropic virus type I (HTLV-I) gp46 outer membrane envelope, MTA-4 (residues 129-203), reacted by Western blot with sera from HTLV-I-infected individuals from the United States and Jamaica but not with 24 (10%) of 242 Japanese sera. A related gp46 recombinant protein, MTA-1 (residues 162-209), reacted with all 58 sera from HTLV-I-infected US and Jamaican individuals and 238 of 242 sera from infected Japanese (combined sensitivity of 99%). Neither recombinant showed reactivity to sera from HTLV-II-infected individuals or uninfected controls. The reactivity of recombinant proteins containing the region of HTLV-II gp46 analogous to MTA-1 was also evaluated by Western blot: GH2-K15 (residues 157-205) and GH2-K55 (residues 162-205) reacted with 88 (98%) and 89 (99%), respectively, of 90 sera from HTLV-II-infected individuals but not with sera from HTLV-I-infected individuals or uninfected controls. These recombinant proteins should permit the development of assays to unambiguously confirm and differentiate HTLV-I and HTLV-II infections.

View details for Web of Science ID A1992HF38700011