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THE P300 EVENT-RELATED POTENTIAL - THE EFFECTS OF SLEEP-DEPRIVATION JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE Morris, A. M., YUEN, S., Lee, K. A., LASH, A. A., BECKER, C. E. 1992; 34 (12): 1143-1152

Abstract

We monitored 15 healthy young adults during 18 hours of sleep deprivation. Subjects were repeatedly tested on measures of the P300 (P3) event-related potential, reaction time, body temperature, and a subjective rating of fatigue. Statistically significant decreases in P3 amplitude (P < or = .01) and increases in P3 latency (P < or = .0001) were found during sleep deprivation. These changes correlated with body temperature and fatigue and were not due to circadian variation. Reaction time did not show a significant change over time. We conclude that the P3 potential is a more sensitive cognitive measure of sleep deprivation than reaction time, a measure commonly used in previous studies. We provide a review of the literature on the P3 and recommend the use of the P3 as a marker to examine sleep deprivation in health professionals.

View details for Web of Science ID A1992KB89400001

View details for PubMedID 1464782