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Cell viability after osteotomy and bone harvesting: comparison of piezoelectric surgery and conventional bur INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY Mouraret, S., Houschyar, K. S., Hunter, D. J., Smith, A. A., Jew, O. S., Girod, S., Helms, J. A. 2014; 43 (8): 966-971

Abstract

The aim of this study was to evaluate and compare the influence of a piezoelectric device versus a conventional bur on osteocyte viability and osteoblast and osteoclast activity using an in vivo mouse model. Osteotomies were created and bone grafts were harvested using either a conventional bur or a piezoelectric device; the resulting injuries and bone grafts were evaluated over an extended time-course using molecular and cellular assays for cell death (TUNEL assay), cell viability (4',6-diamidino-2-phenylindole (DAPI) staining), the onset of mineralization (alkaline phosphatase activity), and bone remodelling (tartrate-resistant acid phosphatase activity). Osteotomies created with a piezoelectric device showed greater osteocyte viability and reduced cell death. Bone grafts harvested with a piezoelectric device exhibited greater short-term cell viability than those harvested with a bur, and exhibited slightly more new bone deposition and bone remodelling. The difference in response of osteocytes, osteoblasts, and osteoclasts to bone cutting via a bur and via a piezoelectric device is negligible in vivo. Given the improved visibility and the margin of safety afforded by a piezoelectric device, they are the instrument of choice when cutting or harvesting bone to preserve soft tissue.

View details for DOI 10.1016/j.ijom.2013.11.018

View details for Web of Science ID 000339601900009

View details for PubMedID 24721169