Bone morphogenic protein-2 gene therapy for mandibular distraction osteogenesis 20th Annual Meeting of the Northeastern-Society-of-Plastic-Surgeons Ashinoff, R. L., Cetrulo, C. L., Galiano, R. D., Dobryansky, M., Bhatt, K. A., Ceradini, D. J., Michaels, J., McCarthy, J. G., Gurtner, G. C. LIPPINCOTT WILLIAMS & WILKINS. 2004: 585–91

Abstract

Distraction osteogenesis (DO) requires a long consolidation period and has a low but real failure rate. Bone morphogenic proteins (BMPs) accelerate bone deposition in fractures and critical-sized bone defects, but their effects on mandibular DO are unknown. We investigated the effect of local delivery of adenovirus containing the gene for BMP-2 (Adbmp-2) on mandibular DO in a rat model. Rats (n = 54) were distracted to 3 mm over 6 days. At the start of consolidation (POD 10), Adbmp-2 or adenovirus containing the lacZgene (AdlacZ) was injected directly into the distraction zone. After 1, 2, and 4 weeks of consolidation, mandibles were evaluated for amount of bone deposition. Adbmp-2-treated specimens demonstrated an increased amount of new bone formation by radiographic, histologic, and histomorphometric analysis. This study demonstrates that local, adenovirally-mediated delivery of BMP-2 can increase bone deposition during DO, potentially shortening consolidation and enhancing DO in poorly healing mandibles, such as occurs postirradiation.

View details for DOI 10.1097/01.sap.0000123.23.28874.1e

View details for Web of Science ID 000221715400011

View details for PubMedID 15166991