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A CLINICAL AND EPIDEMIOLOGIC-STUDY OF HUMAN-LEUKOCYTE ANTIGEN-DPB ALLELES IN HODGKINS-DISEASE CANCER RESEARCH Oza, A. M., Tonks, S., Lim, J., FLEETWOOD, M. A., Lister, T. A., Bodmer, J. G., Howell, W. M., Devereux, S., Taylor, G. M., GOKALE, D., Loeliger, C., Kuehnl, P., Pellegris, G., Takacs, K., Petranyi, G., Gazit, E., Klein, T., Dutoit, E., Martell, R., Hammond, M. G., VANTONDER, S. V., Liang, R., Wong, T., Chan, V., Klitz, W., Begovich, A., Woodfield, G., Roberts, M., Bignon, J. D., Mikata, A., Takenouchi, T., Cunningham, D., Robinson, E., Haim, N., Chen, P. M., Ferreira, E., Whitehouse, J. M., Sweetenham, J., Mead, G. M., Crowther, D., Woll, P., ZELLER, W., Hossfeld, D. K., KUSE, W., Bonadonna, G., Molnar, Z., ECKHARDT, S., BENBASSAT, I., Jacobs, P., Johnson, C., KENOYER, D. J., Todd, D., Chan, T. K., Horning, S., Rosenberg, S., Harvey, V., Thompson, P., Browett, P., Harousseau, J. L. 1994; 54 (19): 5101-5105

Abstract

An international study to investigate the role of human leukocyte antigen (HLA)-DPB alleles in Hodgkin's disease was conducted with 17 participating centers in 12 countries. A total of 741 patients and 686 controls were typed using polymerase chain reaction amplification of HLA-DPB alleles and subsequent sequence specific oligonucleotide hybridization. The frequency of HLA-DPB1*0301 was found to be significantly increased in white patients, compared with ethnically matched controls. In this population group, the DPB1*0301 allele is associated with a relative risk of 1.95 (P < 0.01). There was also a significant reduction in the frequency of HLA-DPB1*0401 in patients from Japan and Taiwan (relative risk, 0.15; P < 0.01). Clinical analysis from data on 551 patients demonstrated a significantly inferior remission duration in patients with HLA-DPB1*0901, overall (P < 0.05), and in the Japanese and Taiwanese populations (P = 0.02), where this allele is most prevalent. This analysis suggests an epidemiological as well as a possible prognostic association between HLA-DPB alleles and Hodgkin's disease.

View details for Web of Science ID A1994PH77400016