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Circuit dynamics of adaptive and maladaptive behaviour NATURE Deisseroth, K. 2014; 505 (7483): 309-317

Abstract

The recent development of technologies for investigating specific components of intact biological systems has allowed elucidation of the neural circuitry underlying adaptive and maladaptive behaviours. Investigators are now able to observe and control, with high spatio-temporal resolution, structurally defined intact pathways along which electrical activity flows during and after the performance of complex behaviours. These investigations have revealed that control of projection-specific dynamics is well suited to modulating behavioural patterns that are relevant to a broad range of psychiatric diseases. Structural dynamics principles have emerged to provide diverse, unexpected and causal insights into the operation of intact and diseased nervous systems, linking form and function in the brain.

View details for DOI 10.1038/nature12982

View details for Web of Science ID 000329621800028

View details for PubMedID 24429629

View details for PubMedCentralID PMC4069282