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Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity

Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity NATURE IMMUNOLOGY Stock, P., Akbari, O., Berry, G., Freeman, G. J., DeKruyff, R. H., Umetsu, D. T. 2004; 5 (11): 1149-1156

Abstract

The range of regulatory T cell (T(R) cell) types that control immune responses is poorly understood. We describe here a population of T(R) cells that developed in vivo from naive CD4(+)CD25(-) T cells during a T helper type 1 (T(H)1)-polarized response, distinct from CD25(+) T(R) cells. These antigen-specific T(R) cells were induced by CD8alpha(+) DCs, produced both interleukin 10 and interferon-gamma, and potently inhibited the development of airway hyper-reactivity. These T(R) cells expressed the transcription factors Foxp3 and T-bet, indicating that these T(R) cells are related to T(H)1 cells. Thus, adaptive T(R) cells are heterogeneous and comprise T(H)1-like T(R) cells as well as previously described T(H)2-like T(R) cells, which express Foxp3 and are induced during the development of respiratory tolerance by CD8alpha(-) DCs.

View details for DOI 10.1038/ni1122

View details for Web of Science ID 000224692700012

View details for PubMedID 15448689