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Increased frontal cortical folding in autism: a preliminary MRI study

Increased frontal cortical folding in autism: a preliminary MRI study PSYCHIATRY RESEARCH-NEUROIMAGING Hardan, A. Y., Jou, R. J., Keshavan, M. S., Varma, R., Minshew, N. J. 2004; 131 (3): 263-268

Abstract

The gyrification index (GI), the ratio of total to outer cortical contour, was applied to measure the cerebral folding patterns in autism. GI was examined on a frontal coronal slice obtained from MRI scans of 30 nonmentally retarded individuals with autism and 32 matched healthy controls. In the autistic group, left frontal GI was higher in children and adolescents but not in adults. Cortical folding was decreased bilaterally with age in the total autistic sample but not in controls. These preliminary findings suggest that the gyrification patterns in autism may be abnormal, which could be related to the various cortical anomalies observed in this disorder.

View details for DOI 10.1016/j.pscychresns.2004.06.001

View details for Web of Science ID 000224608800008

View details for PubMedID 15465295