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A HIPPOCAMPAL PROTEIN ASSOCIATED WITH PARANEOPLASTIC NEUROLOGIC SYNDROME AND SMALL-CELL LUNG-CARCINOMA BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Sakai, K., GOFUKU, M., Kitagawa, Y., Ogasawara, T., Hirose, G., Yamazaki, M., Koh, C. S., Yanagisawa, N., Steinman, L. 1994; 199 (3): 1200-1208

Abstract

A hippocampal 38 kd autoantigen recognized by an autoantibody from the serum of a patient with paraneoplastic limbic encephalitis (PLE) and small cell lung carcinoma (SCLC) was isolated by screening a human hippocampal cDNA library. The 1,991-nucleotide ple21 clone was obtained and the deduced 350-residue protein encoded by the ple21 cDNA clone was found to be highly homologous to the neuron-specific RNA recognition motifs (RRMs)-containing proteins. The homologies were confined to the RRMs and the RRM connecting region. The presence of RRM in the antigenic protein may be important in the pathogenesis of SCLC-associated paraneoplastic neurologic syndrome.

View details for Web of Science ID A1994ND17600017

View details for PubMedID 7511893