We observed a previously uncharacterized mutation in the protease substrate cleft, L23I, in 31 of 4,303 persons undergoing human immunodeficiency virus type 1 genotypic resistance testing. In combination with V82I, L23I was associated with a sevenfold reduction in nelfinavir susceptibility and a decrease in replication capacity. In combination with other drug resistance mutations, L23I was associated with multidrug resistance and a compensatory increase in replication capacity.
View details for DOI 10.1128/AAC.48.12.4864-4868.2004
View details for Web of Science ID 000225474500052
View details for PubMedID 15561868
View details for PubMedCentralID PMC529213