Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

Learn about the flu shot, COVID-19 vaccine, and our masking policy »

Stanford Health Care

CHARACTERIZATION OF LYMPHOMA-DERIVED CELL-LINES - COMPARISON OF CELL-LINES POSITIVE AND NEGATIVE FOR EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN .2. SURFACE-MARKERS JOURNAL OF THE NATIONAL CANCER INSTITUTE Magrath, I. T., Freeman, C. B., Pizzo, P., Gadek, J., Jaffe, E., Santaella, M., Hammer, C., Frank, M., Reaman, G., NOVIKOVS, L. 1980; 64 (3): 477-483

Abstract

Fifteen of 16 lymphoma-derived cell lines and the Faji and P3HR1 cell lines were characterized with regard to certain surface markers, particularly immunoglobulins, complement receptors, Epstein-Barr virus (EBV) receptors, and Fc receptors. Ten lines positive for EBV nuclear antigen (EB-pos) were stained weakly or not at all by antihuman immunoglobulin fluorescein isothiocyanate conjugates, whereas EBV nuclear antigen negative (EB-neg) cell lines stained brightly. EB-pos lines frequently manifested Fc receptors, particularly for 7S antibody, whereas EB-neg lines did not. Receptors for the C3b component of complement and for EBV, which correlated significantly with each other, were expressed to a much lesser extent by EB-neg lines than by EB-pos lines. These findings are pertinent to an understanding of the infrequent association of this virus with American undifferentiated lymphomas of the Burkitt's and non-Burkitt's types.

View details for Web of Science ID A1980JJ53600011

View details for PubMedID 6243722