Gender differences in sleep disordered breathing: implications for therapy EXPERT REVIEW OF RESPIRATORY MEDICINE Won, C., Guilleminault, C. 2015; 9 (2): 221-231


There are gender differences in the upper airway function and respiratory stability in obstructive sleep apnea (OSA). Hormones are implicated in some gender-related differences, and these differences between men and women appear to mitigate as age increases. In addition, changes in the airway and lung function during pregnancy can contribute to snoring and OSA that might have an adverse effect on the mother and fetus. The limited data available suggest that although the prevalence and severity of OSA may be lower in women, the consequences of the disease are similar, if not worse. Women with OSA may have greater risk for hypertension and endothelial dysfunction, be more likely to develop comorbid conditions such as anxiety and depression and have increased mortality. Therefore, treatment options specifically targeting female presentations and pathophysiology of sleep-disordered breathing (SDB) are expected to result in improved outcomes in women.

View details for DOI 10.1586/17476348.2015.1019478

View details for Web of Science ID 000355321300011

View details for PubMedID 25739831