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Abstract
The findings of the Women's Health Initiative (WHI) estrogen plus progestin (E+P) trial led to a substantial reduction in use of combined hormone therapy (cHT) among postmenopausal women in the United States. The economic effect of this shift has not been evaluated relative to the trial's $260 million cost (2012 U.S. dollars).To estimate the economic return from the WHI E+P trial.Decision model to simulate health outcomes for a "WHI scenario" with observed cHT use and a "no-WHI scenario" with cHT use extrapolated from the pretrial period.Primary analyses of WHI outcomes, peer-reviewed literature, and government sources.Postmenopausal women in the United States, aged 50 to 79 years, who did not have a hysterectomy.2003 to 2012.Payer.Combined hormone therapy.Disease incidence, expenditure, quality-adjusted life-years, and net economic return.The WHI scenario resulted in 4.3 million fewer cHT users, 126,000 fewer breast cancer cases, 76,000 fewer cardiovascular disease cases, 263,000 more fractures, 145,000 more quality-adjusted life-years, and expenditure savings of $35.2 billion. The corresponding net economic return of the trial was $37.1 billion ($140 per dollar invested in the trial) at a willingness-to-pay level of $100,000 per quality-adjusted life-year.The 95% CI for the net economic return of the trial was $23.1 to $51.2 billion.No evaluation of indirect costs or outcomes beyond 2012.The WHI E+P trial made high-value use of public funds with a substantial return on investment. These results can contribute to discussions about the role of public funding for large, prospective trials with high potential for public health effects.National Heart, Lung, and Blood Institute.
View details for DOI 10.7326/M13-2348
View details for PubMedID 24798522