Abstract

Whereas conventional actuarial overall survival (OS) estimates rely exclusively on static factors determined around the time of surgery, conditional survival (CS) estimates take into account the years that a patient has already survived.To define the CS of patients following liver resection for intrahepatic cholangiocarcinoma (ICC).Between January 1, 1990, and December 31, 2013, a total of 535 patients who underwent resection of ICC were identified from an international multi-institutional database. In this retrospective international study conducted from January to June 2014, clinicopathological characteristics, operative details, and long-term survival data were analyzed. Conditional survival estimates were calculated as the probability of survival for an additional 3 years.Resection of ICC.Overall survival and CS.While actuarial OS decreased over time from 39% at 3 years to 16% at 8 years (P?=?.002), the 3-year CS (CS3) increased over time among those patients who survived. The CS3 at 5 years-the probability of surviving to postoperative year 8 after having already survived to postoperative year 5-was 65% compared with 8-year OS of 16% (P?=?.002). Factors that were associated with worse OS included larger tumor size (hazard ratio [HR], 1.02; 95% CI, 1.00-1.05; P?=?.05), multifocal disease (HR, 1.49; 95% CI, 1.19-1.86; P?=?.01), lymph node metastasis (HR, 2.21; 95% CI, 1.67-2.93; P?

View details for DOI 10.1001/jamasurg.2015.0219

View details for Web of Science ID 000356615400011

View details for PubMedID 25831462