NON-HODGKINS-LYMPHOMA CONTAINING BOTH B-CELL AND T-CELL CLONES BLOOD Hu, E., Weiss, L. M., Warnke, R., Sklar, J. 1987; 70 (1): 287-292

Abstract

We describe a patient in whom two lymph node biopsies removed 18 months apart disclosed histologic and immunophenotypic evidence of a non-Hodgkin's lymphoma containing neoplastic lymphocytes of both B and T type. Analyses of immunoglobulin and T cell receptor genes confirmed the presence of separate B and T cell clones. In addition, immunogenotyping revealed the possibility of a second B cell clone within the patient's tumor. Development of a multiclonal lymphoma in this patient may relate to the carcinogenic effects of chemotherapy or to a predisposition for neoplastic transformation of lymphocytes due to a previously diagnosed autoimmune condition. Another possible explanation is that the lymphoma implies the existence in this patient of a transformed lymphocyte-committed stem cell that is capable of generating both B and T lineage clones.

View details for Web of Science ID A1987J078000043

View details for PubMedID 2885049