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THE ANTIBODY CROSS-MATCH IN LIVER-TRANSPLANTATION SURGERY Gordon, R. D., Fung, J. J., Markus, B., Fox, I., Iwatsuki, S., Esquivel, C. O., Tzakis, A., Todo, S., Starzl, T. E. 1986; 100 (4): 705-715

Abstract

Six hundred sixty-seven first, second, and third orthotopic liver allografts in 520 patients were reviewed to determine the effect of recipient panel-reactive antibody (PRA) and donor-recipient antibody crossmatch on 2-year patient and liver allograft survival rates. Neither a high panel-reactive antibody nor a positive crossmatch for donor-specific preformed antibody was associated with decreased patient or liver allograft survival for primary grafts or retransplants. Two patients have been given kidney transplants immediately after a liver allograft from a donor with whom each patient had an initial strongly positive donor-specific antibody crossmatch. The liver apparently removed or neutralized circulating anti-donor antibody, since the renal allografts functioned promptly and did not experience hyperacute rejection.

View details for Web of Science ID A1986E313900017

View details for PubMedID 3532391

View details for PubMedCentralID PMC3095820