THE ANTIBODY CROSS-MATCH IN LIVER-TRANSPLANTATION SURGERY Gordon, R. D., Fung, J. J., Markus, B., Fox, I., Iwatsuki, S., Esquivel, C. O., Tzakis, A., Todo, S., Starzl, T. E. 1986; 100 (4): 705-715


Six hundred sixty-seven first, second, and third orthotopic liver allografts in 520 patients were reviewed to determine the effect of recipient panel-reactive antibody (PRA) and donor-recipient antibody crossmatch on 2-year patient and liver allograft survival rates. Neither a high panel-reactive antibody nor a positive crossmatch for donor-specific preformed antibody was associated with decreased patient or liver allograft survival for primary grafts or retransplants. Two patients have been given kidney transplants immediately after a liver allograft from a donor with whom each patient had an initial strongly positive donor-specific antibody crossmatch. The liver apparently removed or neutralized circulating anti-donor antibody, since the renal allografts functioned promptly and did not experience hyperacute rejection.

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