Hematopoietic Cell Transplantation Outcomes in Monosomal Karyotype Myeloid Malignancies. Biology of blood and marrow transplantation Pasquini, M. C., Zhang, M., Medeiros, B. C., Armand, P., Hu, Z., Nishihori, T., AlJurf, M. D., Akpek, G., Cahn, J., Cairo, M. S., Cerny, J., Copelan, E. A., Deol, A., Freytes, C. O., Gale, R. P., Ganguly, S., George, B., Gupta, V., Hale, G. A., Kamble, R. T., Klumpp, T. R., Lazarus, H. M., Luger, S. M., Liesveld, J. L., Litzow, M. R., Marks, D. I., Martino, R., Norkin, M., Olsson, R. F., Oran, B., Pawarode, A., Pulsipher, M. A., Ramanathan, M., Reshef, R., Saad, A. A., Saber, W., Savani, B. N., Schouten, H. C., Ringdén, O., Tallman, M. S., Uy, G. L., Wood, W. A., Wirk, B., Pérez, W. S., Batiwalla, M., Weisdorf, D. J. 2016; 22 (2): 248-257


The presence of monosomal karyotype (MK+) in acute myeloid leukemia (AML) is associated with dismal outcomes. We evaluated the impact of MK+ in AML (MK+AML, n = 240) and in myelodysplastic syndrome (MDS) (MK+MDS, n = 221) on hematopoietic cell transplantation outcomes compared with other cytogenetically defined groups (AML, n = 3360; MDS, n = 1373) as reported to the Center for International Blood and Marrow Transplant Research from 1998 to 2011. MK+ AML was associated with higher disease relapse (hazard ratio, 1.98; P < .01), similar transplantation-related mortality (TRM) (hazard ratio, 1.01; P = .90), and worse survival (hazard ratio, 1.67; P < .01) compared with those outcomes for other cytogenetically defined AML. Among patients with MDS, MK+ MDS was associated with higher disease relapse (hazard ratio, 2.39; P < .01), higher TRM (hazard ratio, 1.80; P < .01), and worse survival (HR, 2.02; P < .01). Subset analyses comparing chromosome 7 abnormalities (del7/7q) with or without MK+ demonstrated higher mortality for MK+ disease in for both AML (hazard ratio, 1.72; P < .01) and MDS (hazard ratio, 1.79; P < .01). The strong negative impact of MK+ in myeloid malignancies was observed in all age groups and using either myeloablative or reduced-intensity conditioning regimens. Alternative approaches to mitigate disease relapse in this population are needed.

View details for DOI 10.1016/j.bbmt.2015.08.024

View details for PubMedID 26327629