Targeting the IRE1 alpha-XBP1 branch of the unfolded protein response in human diseases SEMINARS IN CANCER BIOLOGY Jiang, D., Niwa, M., Koong, A. C. 2015; 33: 48-56

Abstract

Accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) leads to ER stress, which is characteristic of cells with high level of secretory activity and implicated in a variety of disease conditions. In response to ER stress, the cell elicits an adaptive process called the unfolded protein response (UPR) to support cellular homeostasis and survival. However, prolonged and unsolvable ER stress also induces apoptosis. As the most conserved signaling branch of the UPR, the IRE1a-XBP1 pathway plays important roles in both physiological and pathological settings and its activity has profound effects on disease progression and prognosis. Recently, modulating this pathway with small molecule compounds has been demonstrated as a promising approach for disease therapy. In this review, we summarize a list of current investigational compounds targeting this pathway and their therapeutic features for treating human diseases.

View details for DOI 10.1016/j.semcancer.2015.04.010

View details for Web of Science ID 000359887100007

View details for PubMedID 25986851