Bone structure and turnover in type 2 diabetes mellitus OSTEOPOROSIS INTERNATIONAL Shu, A., Yin, M. T., Stein, E., Cremers, S., Dworakowski, E., Ives, R., Rubin, M. R. 2012; 23 (2): 635-641

Abstract

We compared skeletal parameters in type 2 diabetic (T2DM) and non-diabetic postmenopausal women. Bone structure by dual energy x-ray absorptiometry (DXA) and HR-pQCT was not different, although procollagen type 1 amino-terminal propeptide (P1NP) and osteocalcin levels were lower in T2DM.T2DM is associated with increased fracture risk, but, paradoxically, with higher cross-sectional bone density (BMD) as measured by DXA. We sought explanations to this puzzle by investigating detailed structural and biochemical skeletal parameters in T2DM.Cross-sectional comparison of 25 postmenopausal T2DM women and 25 matched controls using DXA, high-resolution peripheral quantitative computed tomography (HR-pQCT) and biochemical bone turnover markers.BMD by DXA did not differ between T2DM and controls. HR-pQCT assessment also did not differ, with the exception of cortical area at the tibia, which tended to be lower in the diabetics (difference of 12?±?6 [mean ± SD] mm, p?=?0.06). P1NP and osteocalcin levels were lower in T2DM as compared to controls (P1NP, 34.3?±?16 vs. 57.3?±?28 ng/ml; p?=?0.005; osteocalcin, 4.5?±?2 vs. 6.2?±?2 nmol/L; p?=?0.001).Postmenopausal women with T2DM had lower levels of bone formation markers as compared to controls. Aside from a possible decrease in cortical bone area at a weight-bearing site, bone structure was not altered in T2DM. Lower bone turnover may be a skeletal parameter that is present in T2DM.

View details for DOI 10.1007/s00198-011-1595-0

View details for Web of Science ID 000299306300024

View details for PubMedID 21424265