Neutrophil-lymphocyte and platelet-lymphocyte ratio as predictors of disease specific survival after resection of adrenocortical carcinoma JOURNAL OF SURGICAL ONCOLOGY Bagante, F., Tran, T. B., Postlewait, L. M., Maithel, S. K., Wang, T. S., Evans, D. B., Hatzaras, I., Shenoy, R., Phay, J. E., Keplinger, K., Fields, R. C., Jin, L. X., Weber, S. M., Salem, A., Sicklick, J. K., Gad, S., Yopp, A. C., Mansour, J. C., Duh, Q., Seiser, N., Solorzano, C. C., Kiernan, C. M., Votanopoulos, K. I., Levine, E. A., Poultsides, G. A., Pawlik, T. M. 2015; 112 (2): 164-172

Abstract

The systemic inflammatory response may be associated with tumor progression. We sought to analyze the impact of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) on recurrence-free survival (RFS) and disease-specific survival (DSS) among patients who underwent surgery for adrenocortical carcinoma (ACC).Patients undergoing surgery for ACC were identified from a multi-center database. Cut-off values of 5 and 190 were defined as elevated NLR and PLR, respectively, and long-term outcome was assessed.Among 84 patients with ACC, 29 (34.%) had NLR?>?5 while 32 (40.5%) had PLR?>?190. NLR and PLR were associated with larger tumors (NLR?>?5: = 5?cm, 0% vs. >5?cm, 39.7%; PLR?>?190: =?5cm, 0% vs. >5?cm, 45.7%), as well as need to resect of other organs (NLR?>?5: other organ resected 48.8% vs. not resected 20.9%; PLR?>?190: other organ resected 25.0% vs. not resected 56.4%)(all P? ?5, 10.5%) and PLR (PLR?=?190: 19.4% vs. PLR?>?190: 5.2%) (both P?

View details for DOI 10.1002/jso.23982

View details for Web of Science ID 000360094300008

View details for PubMedCentralID PMC4962528