The systemic inflammatory response may be associated with tumor progression. We sought to analyze the impact of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) on recurrence-free survival (RFS) and disease-specific survival (DSS) among patients who underwent surgery for adrenocortical carcinoma (ACC).Patients undergoing surgery for ACC were identified from a multi-center database. Cut-off values of 5 and 190 were defined as elevated NLR and PLR, respectively, and long-term outcome was assessed.Among 84 patients with ACC, 29 (34.%) had NLR?>?5 while 32 (40.5%) had PLR?>?190. NLR and PLR were associated with larger tumors (NLR?>?5: = 5?cm, 0% vs. >5?cm, 39.7%; PLR?>?190: =?5cm, 0% vs. >5?cm, 45.7%), as well as need to resect of other organs (NLR?>?5: other organ resected 48.8% vs. not resected 20.9%; PLR?>?190: other organ resected 25.0% vs. not resected 56.4%)(all P? ?5, 10.5%) and PLR (PLR?=?190: 19.4% vs. PLR?>?190: 5.2%) (both P?
View details for DOI 10.1002/jso.23982
View details for Web of Science ID 000360094300008
View details for PubMedCentralID PMC4962528