AMH in women with diminished ovarian reserve: potential differences by FMR1 CGG repeat level. Journal of assisted reproduction and genetics Pastore, L. M., McMurry, T. L., Williams, C. D., Baker, V. L., Young, S. L. 2014; 31 (10): 1295-1301

Abstract

We explored whether AMH, as a surrogate for oocyte supply, varies by FMR1 genotype in women diagnosed with diminished ovarian reserve (DOR), a subset of the Primary Ovarian Insufficiency phenotype. Research is inconsistent on the relationship between AMH and FMR1 repeat length, controlling for age.Seventy-nine cycling women diagnosed with DOR, and without a family history of fragile X syndrome, provided blood for FMR1 and AMH testing. DOR was defined as elevated FSH and/or low AMH and/or low antral follicle count, with regular menses. FMR1 CGG repeats were stratified by the larger allele <35 repeats (n?=?70) v. =35 repeats (n?=?9). Quadratic and linear models were fit to predict log (AMH) controlling for age. The AMH sample used as the outcome variable was drawn at a later date than the diagnostic AMH.Serum AMH concentration median was 0.30 ng/mL; Ages ranged from 26-43 years. A quadratic model (including age(2)) did not show a relationship with FMR1 CGG level (p-value?=?0.25). A linear model of log (AMH), corresponding to an exponential decline of AMH with increasing age, was significantly different, and had a steeper slope, for women with =?35 CGG repeats than women with

View details for DOI 10.1007/s10815-014-0276-2

View details for PubMedID 24938362