Incidence and Outcomes of Stricture Formation Postlaryngectomy OTOLARYNGOLOGY-HEAD AND NECK SURGERY Sweeny, L., Golden, J. B., White, H. N., Magnuson, J. S., Carroll, W. R., Rosenthal, E. L. 2012; 146 (3): 395-402


Postlaryngectomy stricture formation and dysphagia negatively affect quality of life and result in nutritional compromise. Understanding risk factors and successful treatment strategies may improve treatment outcomes.Historical cohort study.Tertiary care medical center.Patients at a tertiary care center who underwent a total laryngectomy between 2003 and 2009 (N = 263) were evaluated in a retrospective manner. Patient demographics, comorbidities, tobacco and alcohol usage, dietary outcomes, feeding tube dependence, and treatment modalities were assessed. Management strategies and outcomes were evaluated.Strictures developed in 19% (n = 49) of patients, and the majority (82%) occurred in the first year. Incidences of stricture formation were similar for primary (19%) and salvage laryngectomy (19%) patients. Patients undergoing salvage laryngectomy were 2 times more likely to be reconstructed with a free flap, whereas those undergoing a primary laryngectomy were 3 times more likely to be closed primarily. Tubed flap reconstruction significantly increased the incidence of stricture formation compared to primary closure (P = .02) in salvage laryngectomy cases. In primary laryngectomy patients, stricture formation did not correlate with flap reconstruction (P = .34) or adjuvant radiation therapy (P = .79). Patients who required a single dilation had better dietary outcomes compared to patients who required serial dilations (P = .14). There was no difference in overall disease-free survival in primary vs salvage laryngectomy patients (P = .95).Rates of stricture formation were the same in patients undergoing salvage compared to primary total laryngectomy.

View details for DOI 10.1177/0194599811430911

View details for Web of Science ID 000303545100011

View details for PubMedID 22166968

View details for PubMedCentralID PMC3951323