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Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Flores-Figueroa, E., Gratzinger, D. 2016; 17 (4)

Abstract

We review the murine and human microenvironment and hematopoietic stem cell niche in the context of intact bone marrow architecture in man and mouse, both in normal and in myelodysplastic syndrome marrow. We propose that the complexity of the hematopoietic stem cell niche can usefully be approached in the context of its topobiology, and we provide a model that incorporates in vitro and in vivo models as well as in situ findings from intact human marrow to explain the changes seen in myelodysplastic syndrome patients. We highlight the clinical application of the study of the bone marrow microenvironment and its topobiology in myelodysplastic syndromes.

View details for DOI 10.3390/ijms17040553

View details for Web of Science ID 000374585300132

View details for PubMedID 27089321